Infection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland.

Hdl Handle:
http://hdl.handle.net/10147/126473
Title:
Infection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland.
Authors:
Burns, K; Morris-Downes, M; Fawley, W N; Smyth, E; Wilcox, M H; Fitzpatrick, F
Affiliation:
Department of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland. burnskaren@yahoo.co.uk
Citation:
Infection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland. 2010, 75 (4):287-91 J. Hosp. Infect.
Journal:
The Journal of hospital infection
Issue Date:
Aug-2010
URI:
http://hdl.handle.net/10147/126473
DOI:
10.1016/j.jhin.2010.03.025
PubMed ID:
20621236
Abstract:
Clostridium difficile is an important healthcare-associated pathogen. Hypervirulent strains such as those belonging to ribotype 027 have been widely reported in recent years. A second strain associated with hypervirulence is ribotype 078 and the prevalence of Clostridium difficile infection (CDI) due to this ribotype appears to be increasing. This report describes an outbreak, in which 15cases of CDI due to ribotype 078 were detected in an Irish hospital and from a nursing home in the hospital's catchment area. C. difficile ribotype 078 accounted for 15% of total isolates submitted for ribotyping. The average age of patients with CDI due to ribotype 078 was 76 years. Forty-six percent of patients experienced recurrence of symptoms within eight weeks of diagnosis and CDI was felt to have directly contributed to five of the eight deaths. Use of enhanced DNA fingerprinting identified clusters within the 15 cases and suggested hitherto unrecognised links between some patients with CDI. Such approaches offer the promise to delineate common sources and transmission routes for C. difficile.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Aged, 80 and over; Clostridium Infections; Clostridium difficile; Cross Infection; DNA Fingerprinting; Disease Outbreaks; Feces; Female; Hospital Mortality; Humans; Ireland; Male; Middle Aged; Nursing Homes; Prevalence; Recurrence; Ribotyping
ISSN:
1532-2939

Full metadata record

DC FieldValue Language
dc.contributor.authorBurns, Ken
dc.contributor.authorMorris-Downes, Men
dc.contributor.authorFawley, W Nen
dc.contributor.authorSmyth, Een
dc.contributor.authorWilcox, M Hen
dc.contributor.authorFitzpatrick, Fen
dc.date.accessioned2011-03-31T08:47:02Z-
dc.date.available2011-03-31T08:47:02Z-
dc.date.issued2010-08-
dc.identifier.citationInfection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland. 2010, 75 (4):287-91 J. Hosp. Infect.en
dc.identifier.issn1532-2939-
dc.identifier.pmid20621236-
dc.identifier.doi10.1016/j.jhin.2010.03.025-
dc.identifier.urihttp://hdl.handle.net/10147/126473-
dc.description.abstractClostridium difficile is an important healthcare-associated pathogen. Hypervirulent strains such as those belonging to ribotype 027 have been widely reported in recent years. A second strain associated with hypervirulence is ribotype 078 and the prevalence of Clostridium difficile infection (CDI) due to this ribotype appears to be increasing. This report describes an outbreak, in which 15cases of CDI due to ribotype 078 were detected in an Irish hospital and from a nursing home in the hospital's catchment area. C. difficile ribotype 078 accounted for 15% of total isolates submitted for ribotyping. The average age of patients with CDI due to ribotype 078 was 76 years. Forty-six percent of patients experienced recurrence of symptoms within eight weeks of diagnosis and CDI was felt to have directly contributed to five of the eight deaths. Use of enhanced DNA fingerprinting identified clusters within the 15 cases and suggested hitherto unrecognised links between some patients with CDI. Such approaches offer the promise to delineate common sources and transmission routes for C. difficile.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshClostridium Infections-
dc.subject.meshClostridium difficile-
dc.subject.meshCross Infection-
dc.subject.meshDNA Fingerprinting-
dc.subject.meshDisease Outbreaks-
dc.subject.meshFeces-
dc.subject.meshFemale-
dc.subject.meshHospital Mortality-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNursing Homes-
dc.subject.meshPrevalence-
dc.subject.meshRecurrence-
dc.subject.meshRibotyping-
dc.titleInfection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland. burnskaren@yahoo.co.uken
dc.identifier.journalThe Journal of hospital infectionen
dc.description.provinceLeinster-

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