Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

Hdl Handle:
http://hdl.handle.net/10147/126467
Title:
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
Authors:
Behan, Aine T; van den Hove, Daniel L A; Mueller, Lynn; Jetten, Marlon J A; Steinbusch, Harry W M; Cotter, David R; Prickaerts, Jos
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. abehan@rcsi.ie
Citation:
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. 2011, 21 (1):71-9 Eur Neuropsychopharmacol
Journal:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/126467
DOI:
10.1016/j.euroneuro.2010.07.004
PubMed ID:
20702067
Abstract:
Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
Item Type:
Article
Language:
en
ISSN:
1873-7862

Full metadata record

DC FieldValue Language
dc.contributor.authorBehan, Aine Ten
dc.contributor.authorvan den Hove, Daniel L Aen
dc.contributor.authorMueller, Lynnen
dc.contributor.authorJetten, Marlon J Aen
dc.contributor.authorSteinbusch, Harry W Men
dc.contributor.authorCotter, David Ren
dc.contributor.authorPrickaerts, Josen
dc.date.accessioned2011-03-31T08:05:56Z-
dc.date.available2011-03-31T08:05:56Z-
dc.date.issued2011-01-
dc.identifier.citationEvidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. 2011, 21 (1):71-9 Eur Neuropsychopharmacolen
dc.identifier.issn1873-7862-
dc.identifier.pmid20702067-
dc.identifier.doi10.1016/j.euroneuro.2010.07.004-
dc.identifier.urihttp://hdl.handle.net/10147/126467-
dc.description.abstractPrenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.-
dc.language.isoenen
dc.titleEvidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. abehan@rcsi.ieen
dc.identifier.journalEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacologyen
dc.description.provinceLeinster-

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