Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics.

Hdl Handle:
http://hdl.handle.net/10147/126448
Title:
Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics.
Authors:
Moloney, Michael A; Casey, Rowan G; O'Donnell, David H; Fitzgerald, Patricia; Thompson, Chris; Bouchier-Hayes, David J
Affiliation:
Department of Vascular Surgery, Beaumont Hospital, Dublin, Ireland. tmoloney@rcsi.ie
Citation:
Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. 2010, 7 (4):300-10 Diab Vasc Dis Res
Journal:
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease
Issue Date:
Oct-2010
URI:
http://hdl.handle.net/10147/126448
DOI:
10.1177/1479164110375971
PubMed ID:
20667936
Additional Links:
http://dvr.sagepub.com/content/7/4/300.full.pdf+html
Abstract:
Type 1 diabetics have a well-recognised risk of accelerated cardiovascular disease. Even in the absence of clinical signs there are detectable abnormalities of conduit vessel function. Our group has previously reported reversal of endothelial dysfunction in diabetics with pravastatin. In young asymptomatic smokers, taurine supplementation has a beneficial impact on macrovascular function, assessed by FMD, and shows an up-regulation of nitric oxide from monocyte-endothelial cell interactions. We hypothesise that taurine supplementation reverses early endothelial abnormalities in young male type 1 diabetics, as assessed by applanation tonometry, brachial artery ultrasound and laser Doppler fluximetry. Asymptomatic, male diabetics (n=9) were scanned prior to treatment and then randomised in a double-blind cross-over fashion to receive either 2 weeks placebo or taurine. Control patients (n=10) underwent a baseline scan. Assessed diabetics had detectable, statistically significant abnormalities when compared with controls, in both arterial stiffness (augmentation index) and brachial artery reactivity (FMD). Both of these parameters were returned to control levels with 2 weeks taurine supplementation. In conclusion, 2 weeks taurine supplementation reverses early, detectable conduit vessel abnormalities in young male diabetics. This may have important implications in the long-term treatment of diabetic patients and their subsequent progression towards atherosclerotic disease.
Item Type:
Article
Language:
en
MeSH:
Adult; Blood Pressure; Brachial Artery; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Heart Rate; Humans; Laser-Doppler Flowmetry; Male; Manometry; Taurine; Vasodilation
ISSN:
1752-8984

Full metadata record

DC FieldValue Language
dc.contributor.authorMoloney, Michael Aen
dc.contributor.authorCasey, Rowan Gen
dc.contributor.authorO'Donnell, David Hen
dc.contributor.authorFitzgerald, Patriciaen
dc.contributor.authorThompson, Chrisen
dc.contributor.authorBouchier-Hayes, David Jen
dc.date.accessioned2011-03-31T08:18:23Z-
dc.date.available2011-03-31T08:18:23Z-
dc.date.issued2010-10-
dc.identifier.citationTwo weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. 2010, 7 (4):300-10 Diab Vasc Dis Resen
dc.identifier.issn1752-8984-
dc.identifier.pmid20667936-
dc.identifier.doi10.1177/1479164110375971-
dc.identifier.urihttp://hdl.handle.net/10147/126448-
dc.description.abstractType 1 diabetics have a well-recognised risk of accelerated cardiovascular disease. Even in the absence of clinical signs there are detectable abnormalities of conduit vessel function. Our group has previously reported reversal of endothelial dysfunction in diabetics with pravastatin. In young asymptomatic smokers, taurine supplementation has a beneficial impact on macrovascular function, assessed by FMD, and shows an up-regulation of nitric oxide from monocyte-endothelial cell interactions. We hypothesise that taurine supplementation reverses early endothelial abnormalities in young male type 1 diabetics, as assessed by applanation tonometry, brachial artery ultrasound and laser Doppler fluximetry. Asymptomatic, male diabetics (n=9) were scanned prior to treatment and then randomised in a double-blind cross-over fashion to receive either 2 weeks placebo or taurine. Control patients (n=10) underwent a baseline scan. Assessed diabetics had detectable, statistically significant abnormalities when compared with controls, in both arterial stiffness (augmentation index) and brachial artery reactivity (FMD). Both of these parameters were returned to control levels with 2 weeks taurine supplementation. In conclusion, 2 weeks taurine supplementation reverses early, detectable conduit vessel abnormalities in young male diabetics. This may have important implications in the long-term treatment of diabetic patients and their subsequent progression towards atherosclerotic disease.-
dc.language.isoenen
dc.relation.urlhttp://dvr.sagepub.com/content/7/4/300.full.pdf+html-
dc.subject.meshAdult-
dc.subject.meshBlood Pressure-
dc.subject.meshBrachial Artery-
dc.subject.meshCross-Over Studies-
dc.subject.meshDiabetes Mellitus, Type 1-
dc.subject.meshDiabetic Angiopathies-
dc.subject.meshDietary Supplements-
dc.subject.meshDouble-Blind Method-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHeart Rate-
dc.subject.meshHumans-
dc.subject.meshLaser-Doppler Flowmetry-
dc.subject.meshMale-
dc.subject.meshManometry-
dc.subject.meshTaurine-
dc.subject.meshVasodilation-
dc.titleTwo weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics.en
dc.typeArticleen
dc.contributor.departmentDepartment of Vascular Surgery, Beaumont Hospital, Dublin, Ireland. tmoloney@rcsi.ieen
dc.identifier.journalDiabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Diseaseen
dc.description.provinceLeinster-

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