Mechanisms underlying rapid aldosterone effects in the kidney.

Hdl Handle:
http://hdl.handle.net/10147/126446
Title:
Mechanisms underlying rapid aldosterone effects in the kidney.
Authors:
Thomas, Warren; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ie
Citation:
Mechanisms underlying rapid aldosterone effects in the kidney. 2011, 73:335-57 Annu. Rev. Physiol.
Journal:
Annual review of physiology
Issue Date:
17-Mar-2011
URI:
http://hdl.handle.net/10147/126446
DOI:
10.1146/annurev-physiol-012110-142222
PubMed ID:
20809792
Abstract:
The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.
Item Type:
Article
Language:
en
ISSN:
1545-1585

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Warrenen
dc.contributor.authorHarvey, Brian Jen
dc.date.accessioned2011-03-31T08:02:19Z-
dc.date.available2011-03-31T08:02:19Z-
dc.date.issued2011-03-17-
dc.identifier.citationMechanisms underlying rapid aldosterone effects in the kidney. 2011, 73:335-57 Annu. Rev. Physiol.en
dc.identifier.issn1545-1585-
dc.identifier.pmid20809792-
dc.identifier.doi10.1146/annurev-physiol-012110-142222-
dc.identifier.urihttp://hdl.handle.net/10147/126446-
dc.description.abstractThe steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.-
dc.language.isoenen
dc.titleMechanisms underlying rapid aldosterone effects in the kidney.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ieen
dc.identifier.journalAnnual review of physiologyen
dc.description.provinceLeinster-

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