Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status.

Hdl Handle:
http://hdl.handle.net/10147/126140
Title:
Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status.
Authors:
O'Sullivan, Eoin P; Ashley, David T; Davenport, Colin; Kelly, James; Devlin, Niamh; Crowley, Rachel; Leahy, Austin L; Kelly, Cathal J; Agha, Amar; Thompson, Christopher J; O'Gorman, Donal J; Fitzgerald, Patricia; Smith, Diarmuid
Affiliation:
Department of Diabetes, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, and Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin 9, Ireland.
Citation:
Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status. 2010, 126 (6):e423-7 Thromb. Res.
Journal:
Thrombosis research
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/126140
DOI:
10.1016/j.thromres.2010.09.003
PubMed ID:
20932553
Abstract:
Peripheral arterial disease (PAD) and type 2 diabetes mellitus (DM) are both associated with excessive vascular calcification and elevated levels of inflammatory markers IL-6 and hsCRP. The recently identified Osteoprotegerin(OPG)/RANKL/TRAIL pathway has been implicated in vascular calcification, but data on levels in PAD and effect of co-existent DM are lacking.; 4 groups of patients were recruited - 26 with PAD and DM, 35 with DM alone, 22 with PAD alone, and 21 healthy individuals. Serum OPG, RANKL, TRAIL, hsCRP and IL-6 were measured using commercial ELISA assays. Presence and severity of PAD was defined using ankle brachial index (ABI).; Serum OPG (7.4±0.3 vs.5.8±0.2 pmol/l, p<0.0001), TRAIL (95.5±5.2 ng/ml vs. 76.2±4.4 ng/ml, p=0.006), hsCRP (2.6±0.3 vs. 1.8±0.3 mg/l, p=0.048), and IL-6 (4.1±0.4 vs. 2.9±0.4 pg/ml, p=0.06) were higher in patients with PAD. There was no difference in RANKL. Only OPG was significantly higher in PAD and DM (7.2±0.3 pmol/l) and PAD alone (7.7±0.4 pmol/l) compared to DM only (5.8±0.3 pmol/l) and healthy controls (5.6±0.4 pmol/l), p<0.01, but OPG was no higher in those with DM plus PAD versus those with PAD alone (p<0.3). Only OPG was associated with PAD severity, correlating negatively with ABI (r=-0.26, p=0.03), independent of age, gender, glycaemic status, hsCRP and IL-6.; PAD is associated with higher serum OPG, regardless of the co-existence of DM. This finding, in addition to its correlation with severity of PAD, suggests that OPG may be a novel marker for the presence and severity of PAD, possibly by reflecting the degree of underlying vascular calcification.
Item Type:
Article
Language:
en
ISSN:
1879-2472

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Sullivan, Eoin Pen
dc.contributor.authorAshley, David Ten
dc.contributor.authorDavenport, Colinen
dc.contributor.authorKelly, Jamesen
dc.contributor.authorDevlin, Niamhen
dc.contributor.authorCrowley, Rachelen
dc.contributor.authorLeahy, Austin Len
dc.contributor.authorKelly, Cathal Jen
dc.contributor.authorAgha, Amaren
dc.contributor.authorThompson, Christopher Jen
dc.contributor.authorO'Gorman, Donal Jen
dc.contributor.authorFitzgerald, Patriciaen
dc.contributor.authorSmith, Diarmuiden
dc.date.accessioned2011-03-29T15:03:27Z-
dc.date.available2011-03-29T15:03:27Z-
dc.date.issued2010-12-
dc.identifier.citationOsteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status. 2010, 126 (6):e423-7 Thromb. Res.en
dc.identifier.issn1879-2472-
dc.identifier.pmid20932553-
dc.identifier.doi10.1016/j.thromres.2010.09.003-
dc.identifier.urihttp://hdl.handle.net/10147/126140-
dc.description.abstractPeripheral arterial disease (PAD) and type 2 diabetes mellitus (DM) are both associated with excessive vascular calcification and elevated levels of inflammatory markers IL-6 and hsCRP. The recently identified Osteoprotegerin(OPG)/RANKL/TRAIL pathway has been implicated in vascular calcification, but data on levels in PAD and effect of co-existent DM are lacking.-
dc.description.abstract4 groups of patients were recruited - 26 with PAD and DM, 35 with DM alone, 22 with PAD alone, and 21 healthy individuals. Serum OPG, RANKL, TRAIL, hsCRP and IL-6 were measured using commercial ELISA assays. Presence and severity of PAD was defined using ankle brachial index (ABI).-
dc.description.abstractSerum OPG (7.4±0.3 vs.5.8±0.2 pmol/l, p<0.0001), TRAIL (95.5±5.2 ng/ml vs. 76.2±4.4 ng/ml, p=0.006), hsCRP (2.6±0.3 vs. 1.8±0.3 mg/l, p=0.048), and IL-6 (4.1±0.4 vs. 2.9±0.4 pg/ml, p=0.06) were higher in patients with PAD. There was no difference in RANKL. Only OPG was significantly higher in PAD and DM (7.2±0.3 pmol/l) and PAD alone (7.7±0.4 pmol/l) compared to DM only (5.8±0.3 pmol/l) and healthy controls (5.6±0.4 pmol/l), p<0.01, but OPG was no higher in those with DM plus PAD versus those with PAD alone (p<0.3). Only OPG was associated with PAD severity, correlating negatively with ABI (r=-0.26, p=0.03), independent of age, gender, glycaemic status, hsCRP and IL-6.-
dc.description.abstractPAD is associated with higher serum OPG, regardless of the co-existence of DM. This finding, in addition to its correlation with severity of PAD, suggests that OPG may be a novel marker for the presence and severity of PAD, possibly by reflecting the degree of underlying vascular calcification.-
dc.language.isoenen
dc.titleOsteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diabetes, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, and Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin 9, Ireland.en
dc.identifier.journalThrombosis researchen
dc.description.provinceLeinster-

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