Steroid withdrawal in renal transplant patients: the Irish experience.

Hdl Handle:
http://hdl.handle.net/10147/126132
Title:
Steroid withdrawal in renal transplant patients: the Irish experience.
Authors:
Phelan, P J; Moran, A-M; O'Kelly, P; Heng, P Y; Yussof, S M; Walshe, J J; Magee, C; Conlon, P J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland, paulphel@gmail.com.
Citation:
Steroid withdrawal in renal transplant patients: the Irish experience. 2010: Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
29-Oct-2010
URI:
http://hdl.handle.net/10147/126132
DOI:
10.1007/s11845-010-0626-8
PubMed ID:
21046471
Abstract:
BACKGROUND: Steroid therapy is associated with significant morbidity in renal transplant recipients. However, there is concern that steroid withdrawal will adversely affect outcome. METHODS: We report on 241 renal transplant recipients on different doses of corticosteroids at 3 months (zero, ≤5 mg/day, >5 mg/day). Parameters analysed included blood pressure, lipid profile, weight change, new onset diabetes after transplantation (NODAT), allograft survival and acute rejection. RESULTS: Elimination of corticosteroids had no impact on allograft survival at 1 year. There were no cases of NODAT in the steroid withdrawal group compared with over 7% in each of the steroid groups. There were no significant improvements in weight gain, blood pressure control or total cholesterol with withdrawal of steroids before 3 months. CONCLUSIONS: In renal transplant patients treated with tacrolimus and mycophenolate, early withdrawal of steroids does not appear to adversely affect allograft outcome at 1 year. It may result in less NODAT.
Item Type:
Article In Press
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, P Jen
dc.contributor.authorMoran, A-Men
dc.contributor.authorO'Kelly, Pen
dc.contributor.authorHeng, P Yen
dc.contributor.authorYussof, S Men
dc.contributor.authorWalshe, J Jen
dc.contributor.authorMagee, Cen
dc.contributor.authorConlon, P Jen
dc.date.accessioned2011-03-29T14:50:07Z-
dc.date.available2011-03-29T14:50:07Z-
dc.date.issued2010-10-29-
dc.identifier.citationSteroid withdrawal in renal transplant patients: the Irish experience. 2010: Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid21046471-
dc.identifier.doi10.1007/s11845-010-0626-8-
dc.identifier.urihttp://hdl.handle.net/10147/126132-
dc.description.abstractBACKGROUND: Steroid therapy is associated with significant morbidity in renal transplant recipients. However, there is concern that steroid withdrawal will adversely affect outcome. METHODS: We report on 241 renal transplant recipients on different doses of corticosteroids at 3 months (zero, ≤5 mg/day, >5 mg/day). Parameters analysed included blood pressure, lipid profile, weight change, new onset diabetes after transplantation (NODAT), allograft survival and acute rejection. RESULTS: Elimination of corticosteroids had no impact on allograft survival at 1 year. There were no cases of NODAT in the steroid withdrawal group compared with over 7% in each of the steroid groups. There were no significant improvements in weight gain, blood pressure control or total cholesterol with withdrawal of steroids before 3 months. CONCLUSIONS: In renal transplant patients treated with tacrolimus and mycophenolate, early withdrawal of steroids does not appear to adversely affect allograft outcome at 1 year. It may result in less NODAT.-
dc.languageENG-
dc.titleSteroid withdrawal in renal transplant patients: the Irish experience.en
dc.typeArticle In Pressen
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin 9, Ireland, paulphel@gmail.com.en
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceLeinster-

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