Establishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines.

Hdl Handle:
http://hdl.handle.net/10147/126126
Title:
Establishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines.
Authors:
Griffin, Alison; O'Shea, Paula; FitzGerald, Roland; O'Connor, Gerard; Tormey, William
Affiliation:
Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland. alisongriffin@beaumont.ie
Citation:
Establishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines. 2011, 48 (Pt 1):41-4 Ann. Clin. Biochem.
Journal:
Annals of clinical biochemistry
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/126126
DOI:
10.1258/acb.2010.010062
PubMed ID:
21123298
Abstract:
Normetanephrine and metanephrine are intermediate metabolites of noradrenaline and adrenaline metabolism. To assess whether normetanephrine and metanephrine analysis may aid in the diagnosis of Neuroblastoma, a reference interval for these metabolites must first be established.; The overall aim of this study was to establish a paediatric age-related reference interval for the measurement of total fractionated metanephrines.; A total of 267 urine samples were analysed following acid hydrolysis. This releases the metanephrines from their sulphate-bound metabolites. The samples were analysed using reverse phase high-performance liquid chromatography with electro-chemical detection on a Gilson automated sequential trace enrichment of dialysate sample system.; Data were analysed using Minitab Release version 14. Outliers were removed using the Dixon/Reed one-third rule. Partitioning of the age groups was achieved using Harris and Boyd's standard normal deviate test. Non-parametric analysis of the data was performed, followed by the establishment of the 2.5th and the 97.5th reference limits.; The established reference intervals are described in Table 2.
Item Type:
Article
Language:
en
ISSN:
1758-1001

Full metadata record

DC FieldValue Language
dc.contributor.authorGriffin, Alisonen
dc.contributor.authorO'Shea, Paulaen
dc.contributor.authorFitzGerald, Rolanden
dc.contributor.authorO'Connor, Gerarden
dc.contributor.authorTormey, Williamen
dc.date.accessioned2011-03-29T14:25:36Z-
dc.date.available2011-03-29T14:25:36Z-
dc.date.issued2011-01-
dc.identifier.citationEstablishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines. 2011, 48 (Pt 1):41-4 Ann. Clin. Biochem.en
dc.identifier.issn1758-1001-
dc.identifier.pmid21123298-
dc.identifier.doi10.1258/acb.2010.010062-
dc.identifier.urihttp://hdl.handle.net/10147/126126-
dc.description.abstractNormetanephrine and metanephrine are intermediate metabolites of noradrenaline and adrenaline metabolism. To assess whether normetanephrine and metanephrine analysis may aid in the diagnosis of Neuroblastoma, a reference interval for these metabolites must first be established.-
dc.description.abstractThe overall aim of this study was to establish a paediatric age-related reference interval for the measurement of total fractionated metanephrines.-
dc.description.abstractA total of 267 urine samples were analysed following acid hydrolysis. This releases the metanephrines from their sulphate-bound metabolites. The samples were analysed using reverse phase high-performance liquid chromatography with electro-chemical detection on a Gilson automated sequential trace enrichment of dialysate sample system.-
dc.description.abstractData were analysed using Minitab Release version 14. Outliers were removed using the Dixon/Reed one-third rule. Partitioning of the age groups was achieved using Harris and Boyd's standard normal deviate test. Non-parametric analysis of the data was performed, followed by the establishment of the 2.5th and the 97.5th reference limits.-
dc.description.abstractThe established reference intervals are described in Table 2.-
dc.language.isoenen
dc.titleEstablishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland. alisongriffin@beaumont.ieen
dc.identifier.journalAnnals of clinical biochemistryen
dc.description.provinceLeinster-

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