MicroRNAs in inflammatory lung disease--master regulators or target practice?

Hdl Handle:
http://hdl.handle.net/10147/126119
Title:
MicroRNAs in inflammatory lung disease--master regulators or target practice?
Authors:
Oglesby, Irene K; McElvaney, Noel G; Greene, Catherine M
Affiliation:
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Citation:
MicroRNAs in inflammatory lung disease--master regulators or target practice? 2010, 11:148 Respir. Res.
Journal:
Respiratory research
Issue Date:
2010
URI:
http://hdl.handle.net/10147/126119
DOI:
10.1186/1465-9921-11-148
PubMed ID:
21029443
Abstract:
MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs with immense significance in numerous biological processes. When aberrantly expressed miRNAs have been shown to play a role in the pathogenesis of several disease states. Extensive research has explored miRNA involvement in the development and fate of immune cells and in both the innate and adaptive immune responses whereby strong evidence links miRNA expression to signalling pathways and receptors with critical roles in the inflammatory response such as NF-κB and the toll-like receptors, respectively. Recent studies have revealed that unique miRNA expression profiles exist in inflammatory lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and lung cancer. Evaluation of the global expression of miRNAs provides a unique opportunity to identify important target gene sets regulating susceptibility and response to infection and treatment, and control of inflammation in chronic airway disorders. Over 800 human miRNAs have been discovered to date, however the biological function of the majority remains to be uncovered. Understanding the role that miRNAs play in the modulation of gene expression leading to sustained chronic pulmonary inflammation is important for the development of new therapies which focus on prevention of disease progression rather than symptom relief. Here we discuss the current understanding of miRNA involvement in innate immunity, specifically in LPS/TLR4 signalling and in the progression of the chronic inflammatory lung diseases cystic fibrosis, COPD and asthma. miRNA in lung cancer and IPF are also reviewed.
Item Type:
Article
Language:
en
MeSH:
Gene Expression Regulation; Gene Targeting; Humans; Inflammation; Lung; Lung Diseases; MicroRNAs
ISSN:
1465-993X

Full metadata record

DC FieldValue Language
dc.contributor.authorOglesby, Irene Ken
dc.contributor.authorMcElvaney, Noel Gen
dc.contributor.authorGreene, Catherine Men
dc.date.accessioned2011-03-29T14:55:13Z-
dc.date.available2011-03-29T14:55:13Z-
dc.date.issued2010-
dc.identifier.citationMicroRNAs in inflammatory lung disease--master regulators or target practice? 2010, 11:148 Respir. Res.en
dc.identifier.issn1465-993X-
dc.identifier.pmid21029443-
dc.identifier.doi10.1186/1465-9921-11-148-
dc.identifier.urihttp://hdl.handle.net/10147/126119-
dc.description.abstractMicroRNAs (miRNAs) have emerged as a class of regulatory RNAs with immense significance in numerous biological processes. When aberrantly expressed miRNAs have been shown to play a role in the pathogenesis of several disease states. Extensive research has explored miRNA involvement in the development and fate of immune cells and in both the innate and adaptive immune responses whereby strong evidence links miRNA expression to signalling pathways and receptors with critical roles in the inflammatory response such as NF-κB and the toll-like receptors, respectively. Recent studies have revealed that unique miRNA expression profiles exist in inflammatory lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and lung cancer. Evaluation of the global expression of miRNAs provides a unique opportunity to identify important target gene sets regulating susceptibility and response to infection and treatment, and control of inflammation in chronic airway disorders. Over 800 human miRNAs have been discovered to date, however the biological function of the majority remains to be uncovered. Understanding the role that miRNAs play in the modulation of gene expression leading to sustained chronic pulmonary inflammation is important for the development of new therapies which focus on prevention of disease progression rather than symptom relief. Here we discuss the current understanding of miRNA involvement in innate immunity, specifically in LPS/TLR4 signalling and in the progression of the chronic inflammatory lung diseases cystic fibrosis, COPD and asthma. miRNA in lung cancer and IPF are also reviewed.-
dc.language.isoenen
dc.subject.meshGene Expression Regulation-
dc.subject.meshGene Targeting-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshLung-
dc.subject.meshLung Diseases-
dc.subject.meshMicroRNAs-
dc.titleMicroRNAs in inflammatory lung disease--master regulators or target practice?en
dc.typeArticleen
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalRespiratory researchen
dc.description.provinceLeinster-

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