The regulation of cell growth and survival by aldosterone.

Hdl Handle:
http://hdl.handle.net/10147/126097
Title:
The regulation of cell growth and survival by aldosterone.
Authors:
Dooley, Ruth; Harvey, Brian J; Thomas, Warren
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ruthdooley@rcsi.ie
Citation:
The regulation of cell growth and survival by aldosterone. 2011, 16:440-57 Front. Biosci.
Journal:
Frontiers in bioscience : a journal and virtual library
Issue Date:
2011
URI:
http://hdl.handle.net/10147/126097
PubMed ID:
21196180
Abstract:
The steroid hormone aldosterone is synthesized from cholesterol, mainly in the zona glomerulosa of the adrenal cortex. Aldosterone exerts its effects in the epithelial tissues of the kidney and colon and in non-epithelial tissues such as the brain and cardiovasculature. The genomic response to aldosterone involves dimerization of the mineralocorticoid receptor (MR), dissociation of heat shock proteins from MR, translocation of the aldosterone-MR complex to the nucleus and the concomitant regulation of gene expression. Rapid responses to aldosterone occur within seconds to minutes, do not involve transcription or translation and can modulate directly or indirectly the later genomic responses. Aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. Here we discuss the involvement of aldosterone-mediated rapid signalling cascades in the development of disease states such as chronic kidney disease and heart failure, and the antagonists that can inhibit these pathophysiological responses.
Item Type:
Article
Language:
en
ISSN:
1093-4715

Full metadata record

DC FieldValue Language
dc.contributor.authorDooley, Ruthen
dc.contributor.authorHarvey, Brian Jen
dc.contributor.authorThomas, Warrenen
dc.date.accessioned2011-03-29T14:03:59Z-
dc.date.available2011-03-29T14:03:59Z-
dc.date.issued2011-
dc.identifier.citationThe regulation of cell growth and survival by aldosterone. 2011, 16:440-57 Front. Biosci.en
dc.identifier.issn1093-4715-
dc.identifier.pmid21196180-
dc.identifier.urihttp://hdl.handle.net/10147/126097-
dc.description.abstractThe steroid hormone aldosterone is synthesized from cholesterol, mainly in the zona glomerulosa of the adrenal cortex. Aldosterone exerts its effects in the epithelial tissues of the kidney and colon and in non-epithelial tissues such as the brain and cardiovasculature. The genomic response to aldosterone involves dimerization of the mineralocorticoid receptor (MR), dissociation of heat shock proteins from MR, translocation of the aldosterone-MR complex to the nucleus and the concomitant regulation of gene expression. Rapid responses to aldosterone occur within seconds to minutes, do not involve transcription or translation and can modulate directly or indirectly the later genomic responses. Aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. Here we discuss the involvement of aldosterone-mediated rapid signalling cascades in the development of disease states such as chronic kidney disease and heart failure, and the antagonists that can inhibit these pathophysiological responses.-
dc.language.isoenen
dc.titleThe regulation of cell growth and survival by aldosterone.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ruthdooley@rcsi.ieen
dc.identifier.journalFrontiers in bioscience : a journal and virtual libraryen
dc.description.provinceLeinster-

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