In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.

Hdl Handle:
http://hdl.handle.net/10147/126091
Title:
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.
Authors:
Desgranges, Stephane; Le Prieult, Florie; Daly, Alan; Lydon, Jennifer; Brennan, Marian; Rai, Dilip K; Subasinghage, Anusha P; Hewage, Chandralal M; Cryan, Sally-Ann; Greene, Catherine; McElvaney, Noel G; Smyth, Timothy P; Fitzgerald-Hughes, Deirdre; Humphreys, Hilary; Devocelle, Marc
Affiliation:
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9; Department of Microbiology, Beaumont Hospital, Dublin 9; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Conway Institute, University College Dublin, Belfield, Dublin 4; School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9; and Department of Chemical & Environmental Sciences, University of Limerick, Ireland.
Citation:
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase. 2011:notAntimicrob Agents Chemother
Journal:
Antimicrobial agents and chemotherapy
Issue Date:
22-Feb-2011
URI:
http://hdl.handle.net/10147/126091
DOI:
10.1128/AAC.01384-10
PubMed ID:
21343449
Additional Links:
http://aac.asm.org/cgi/reprint/AAC.01384-10v1?view=long&pmid=21343449
Abstract:
The antimicrobial and haemolytic activities of a host defence peptide can be controlled by modification as a propeptide of reduced net charge which can be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
Item Type:
Article in Press
Language:
null
ISSN:
1098-6596

Full metadata record

DC FieldValue Language
dc.contributor.authorDesgranges, Stephaneen
dc.contributor.authorLe Prieult, Florieen
dc.contributor.authorDaly, Alanen
dc.contributor.authorLydon, Jenniferen
dc.contributor.authorBrennan, Marianen
dc.contributor.authorRai, Dilip Ken
dc.contributor.authorSubasinghage, Anusha Pen
dc.contributor.authorHewage, Chandralal Men
dc.contributor.authorCryan, Sally-Annen
dc.contributor.authorGreene, Catherineen
dc.contributor.authorMcElvaney, Noel Gen
dc.contributor.authorSmyth, Timothy Pen
dc.contributor.authorFitzgerald-Hughes, Deirdreen
dc.contributor.authorHumphreys, Hilaryen
dc.contributor.authorDevocelle, Marcen
dc.date.accessioned2011-03-29T13:43:43Z-
dc.date.available2011-03-29T13:43:43Z-
dc.date.issued2011-02-22-
dc.identifier.citationIn Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase. 2011:notAntimicrob Agents Chemotheren
dc.identifier.issn1098-6596-
dc.identifier.pmid21343449-
dc.identifier.doi10.1128/AAC.01384-10-
dc.identifier.urihttp://hdl.handle.net/10147/126091-
dc.description.abstractThe antimicrobial and haemolytic activities of a host defence peptide can be controlled by modification as a propeptide of reduced net charge which can be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.-
dc.languageENG-
dc.language.isonullen
dc.relation.urlhttp://aac.asm.org/cgi/reprint/AAC.01384-10v1?view=long&pmid=21343449en
dc.titleIn Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.en
dc.typeArticle in Press-
dc.contributor.departmentCentre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9; Department of Microbiology, Beaumont Hospital, Dublin 9; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Conway Institute, University College Dublin, Belfield, Dublin 4; School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9; and Department of Chemical & Environmental Sciences, University of Limerick, Ireland.en
dc.identifier.journalAntimicrobial agents and chemotherapyen
dc.description.provinceLeinster-

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