Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker.

Hdl Handle:
http://hdl.handle.net/10147/126071
Title:
Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker.
Authors:
Buckley, Patrick G; Alcock, Leah; Heffernan, Josephine; Woods, Jack; Brett, Francesca; Stallings, Raymond L; Farrell, Michael A
Affiliation:
The Royal College of Surgeons in Ireland, Cancer Genetics, 2nd Floor York House, York Street, Dublin, Dublin 2, Ireland. pbuckley@rcsi.ie
Citation:
Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker. 2011, 70 (3):177-82 J. Neuropathol. Exp. Neurol.
Journal:
Journal of neuropathology and experimental neurology
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/126071
DOI:
10.1097/NEN.0b013e31820c765b
PubMed ID:
21293300
Abstract:
Loss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in oligodendrogliomas. The aim of this study was to assess further the diagnostic utility of INA expression in a set of genetically well-characterized oligodendrogliomas. On the basis of a conservative approach for copy number determination, using both comparative genomic hybridization and fluorescent in situ hybridization, INA expression as a surrogate marker for 1p/19q loss had both reduced specificity (80%) and sensitivity (79%) compared with respective values of 86% and 96% reported in the previous report. The histologic interpretation and diagnostic value of INA expression in oligodendrogliomas should therefore be assessed with greater caution when compared with 1p/19q DNA copy number analysis. In addition, DNA copy number aberrations of chromosomes 10, 16, and 17 were detected exclusively in 1p/19q codeleted samples, suggesting that other regions of the genome may contribute to the 1p/19q-deleted tumor phenotype inthese samples.
Item Type:
Article
Language:
en
ISSN:
0022-3069

Full metadata record

DC FieldValue Language
dc.contributor.authorBuckley, Patrick Gen
dc.contributor.authorAlcock, Leahen
dc.contributor.authorHeffernan, Josephineen
dc.contributor.authorWoods, Jacken
dc.contributor.authorBrett, Francescaen
dc.contributor.authorStallings, Raymond Len
dc.contributor.authorFarrell, Michael Aen
dc.date.accessioned2011-03-29T13:36:51Z-
dc.date.available2011-03-29T13:36:51Z-
dc.date.issued2011-03-
dc.identifier.citationLoss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker. 2011, 70 (3):177-82 J. Neuropathol. Exp. Neurol.en
dc.identifier.issn0022-3069-
dc.identifier.pmid21293300-
dc.identifier.doi10.1097/NEN.0b013e31820c765b-
dc.identifier.urihttp://hdl.handle.net/10147/126071-
dc.description.abstractLoss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in oligodendrogliomas. The aim of this study was to assess further the diagnostic utility of INA expression in a set of genetically well-characterized oligodendrogliomas. On the basis of a conservative approach for copy number determination, using both comparative genomic hybridization and fluorescent in situ hybridization, INA expression as a surrogate marker for 1p/19q loss had both reduced specificity (80%) and sensitivity (79%) compared with respective values of 86% and 96% reported in the previous report. The histologic interpretation and diagnostic value of INA expression in oligodendrogliomas should therefore be assessed with greater caution when compared with 1p/19q DNA copy number analysis. In addition, DNA copy number aberrations of chromosomes 10, 16, and 17 were detected exclusively in 1p/19q codeleted samples, suggesting that other regions of the genome may contribute to the 1p/19q-deleted tumor phenotype inthese samples.-
dc.language.isoenen
dc.titleLoss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker.en
dc.typeArticleen
dc.contributor.departmentThe Royal College of Surgeons in Ireland, Cancer Genetics, 2nd Floor York House, York Street, Dublin, Dublin 2, Ireland. pbuckley@rcsi.ieen
dc.identifier.journalJournal of neuropathology and experimental neurologyen
dc.description.provinceLeinster-

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