The cystic fibrosis neutrophil: a specialized yet potentially defective cell.

Hdl Handle:
http://hdl.handle.net/10147/126067
Title:
The cystic fibrosis neutrophil: a specialized yet potentially defective cell.
Authors:
Hayes, Elaine; Pohl, Kerstin; McElvaney, Noel G; Reeves, Emer P
Affiliation:
Respiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.
Citation:
The cystic fibrosis neutrophil: a specialized yet potentially defective cell. 2011, 59 (2):97-112 Arch. Immunol. Ther. Exp. (Warsz.)
Journal:
Archivum immunologiae et therapiae experimentalis
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/126067
DOI:
10.1007/s00005-011-0113-6
PubMed ID:
21311988
Abstract:
Cystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite advances in our understanding of the molecular and cellular basis of CF, there remains a paradox of why recruited CF neutrophils fail to eradicate bacterial infections in the lung. This review describes mechanisms involved in neutrophil migration, microbial killing and apoptosis leading to inflammatory resolution. We discuss dysregulated neutrophil activity and consider genetic versus inflammatory neutrophil reprogramming in CF and ultimately pharmacological modulation of the CF neutrophil for therapeutic intervention.
Item Type:
Article
Language:
en
ISSN:
1661-4917

Full metadata record

DC FieldValue Language
dc.contributor.authorHayes, Elaineen
dc.contributor.authorPohl, Kerstinen
dc.contributor.authorMcElvaney, Noel Gen
dc.contributor.authorReeves, Emer Pen
dc.date.accessioned2011-03-29T13:30:07Z-
dc.date.available2011-03-29T13:30:07Z-
dc.date.issued2011-04-
dc.identifier.citationThe cystic fibrosis neutrophil: a specialized yet potentially defective cell. 2011, 59 (2):97-112 Arch. Immunol. Ther. Exp. (Warsz.)en
dc.identifier.issn1661-4917-
dc.identifier.pmid21311988-
dc.identifier.doi10.1007/s00005-011-0113-6-
dc.identifier.urihttp://hdl.handle.net/10147/126067-
dc.description.abstractCystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite advances in our understanding of the molecular and cellular basis of CF, there remains a paradox of why recruited CF neutrophils fail to eradicate bacterial infections in the lung. This review describes mechanisms involved in neutrophil migration, microbial killing and apoptosis leading to inflammatory resolution. We discuss dysregulated neutrophil activity and consider genetic versus inflammatory neutrophil reprogramming in CF and ultimately pharmacological modulation of the CF neutrophil for therapeutic intervention.-
dc.language.isoenen
dc.titleThe cystic fibrosis neutrophil: a specialized yet potentially defective cell.en
dc.typeArticleen
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.en
dc.identifier.journalArchivum immunologiae et therapiae experimentalisen
dc.description.provinceLeinster-

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