The role of biopsy in the diagnosis of infections of the central nervous system.

Hdl Handle:
http://hdl.handle.net/10147/125889
Title:
The role of biopsy in the diagnosis of infections of the central nervous system.
Authors:
Jansen, M; Corcoran, D; Bermingham, N; Keohane, C
Affiliation:
Neurosciences Department, Cork University Hospital Wilton, Cork.
Citation:
The role of biopsy in the diagnosis of infections of the central nervous system. 2010, 103 (1):6-8 Ir Med J
Journal:
Irish medical journal
Issue Date:
Jan-2010
URI:
http://hdl.handle.net/10147/125889
PubMed ID:
20222384
Abstract:
CNS infections require prompt appropriate therapy, but do not usually require tissue biopsy for diagnosis. We performed a 5 year audit of CNS infections which required brain or spinal biopsy to determine or confirm a diagnosis of CNS infection. Sixteen cases were identified in which clinical, radiological or additional investigations including culture, serology or PCR for the suspected specific infective agents were not diagnostic. 6 (37.5%) were bacterial abscesses presenting as space-occupying intracerebral lesions with a differential diagnosis of neoplasm. There were 3 (18.7%) cases of toxoplasmosis and 2 (12.5%) cases of aspergillosis. There was one case (6.2%) of herpes simplex encephalitis, one cysticercosis and one progressive multifocal leucoencephalopathy, all biopsied as possible neoplasms. There were 2 (12.5%) cases of spinal tuberculosis, one multifocal, mimicking neurofibromatosis. This review highlights the usefulness of targeted biopsy in the rapid diagnosis of CNS infections. It also emphasizes the lack of specificity of 'negative' culture and serology in certain cases, especially in the setting of immune-compromise.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Biopsy; Central Nervous System Infections; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Staining and Labeling
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorJansen, Men
dc.contributor.authorCorcoran, Den
dc.contributor.authorBermingham, Nen
dc.contributor.authorKeohane, Cen
dc.date.accessioned2011-03-28T14:49:41Z-
dc.date.available2011-03-28T14:49:41Z-
dc.date.issued2010-01-
dc.identifier.citationThe role of biopsy in the diagnosis of infections of the central nervous system. 2010, 103 (1):6-8 Ir Med Jen
dc.identifier.issn0332-3102-
dc.identifier.pmid20222384-
dc.identifier.urihttp://hdl.handle.net/10147/125889-
dc.description.abstractCNS infections require prompt appropriate therapy, but do not usually require tissue biopsy for diagnosis. We performed a 5 year audit of CNS infections which required brain or spinal biopsy to determine or confirm a diagnosis of CNS infection. Sixteen cases were identified in which clinical, radiological or additional investigations including culture, serology or PCR for the suspected specific infective agents were not diagnostic. 6 (37.5%) were bacterial abscesses presenting as space-occupying intracerebral lesions with a differential diagnosis of neoplasm. There were 3 (18.7%) cases of toxoplasmosis and 2 (12.5%) cases of aspergillosis. There was one case (6.2%) of herpes simplex encephalitis, one cysticercosis and one progressive multifocal leucoencephalopathy, all biopsied as possible neoplasms. There were 2 (12.5%) cases of spinal tuberculosis, one multifocal, mimicking neurofibromatosis. This review highlights the usefulness of targeted biopsy in the rapid diagnosis of CNS infections. It also emphasizes the lack of specificity of 'negative' culture and serology in certain cases, especially in the setting of immune-compromise.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBiopsy-
dc.subject.meshCentral Nervous System Infections-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshStaining and Labeling-
dc.titleThe role of biopsy in the diagnosis of infections of the central nervous system.en
dc.typeArticleen
dc.contributor.departmentNeurosciences Department, Cork University Hospital Wilton, Cork.en
dc.identifier.journalIrish medical journalen

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