The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study.

Hdl Handle:
http://hdl.handle.net/10147/124253
Title:
The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study.
Authors:
Macfarlane, Tatiana V; Macfarlane, Gary J; Oliver, Richard J; Benhamou, Simone; Bouchardy, Christine; Ahrens, Wolfgang; Pohlabeln, Hermann; Lagiou, Pagona; Lagiou, Areti; Castellsague, Xavier; Agudo, Antonio; Merletti, Franco; Richiardi, Lorenzo; Kjaerheim, Kristina; Slamova, Alena; Schejbalova, Miriam; Canova, Cristina; Simonato, Lorenzo; Talamini, Renato; Barzan, Luigi; Conway, David I; McKinney, Patricia A; Znaor, Ariana; Lowry, Raymond J; Thomson, Peter; Healy, Claire M; McCartan, Bernard E; Marron, Manuela; Hashibe, Mia; Brennan, Paul
Affiliation:
School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. Tatiana.Macfarlane@abdn.ac.uk.
Citation:
The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. 2010, 21 (12):2213-21 Cancer Causes Control
Journal:
Cancer causes & control : CCC
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/124253
DOI:
10.1007/s10552-010-9641-3
PubMed ID:
20835759
Abstract:
The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption.; To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years.; A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched.; There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk.; Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike.
Item Type:
Article
Language:
en
ISSN:
1573-7225

Full metadata record

DC FieldValue Language
dc.contributor.authorMacfarlane, Tatiana Ven
dc.contributor.authorMacfarlane, Gary Jen
dc.contributor.authorOliver, Richard Jen
dc.contributor.authorBenhamou, Simoneen
dc.contributor.authorBouchardy, Christineen
dc.contributor.authorAhrens, Wolfgangen
dc.contributor.authorPohlabeln, Hermannen
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorLagiou, Aretien
dc.contributor.authorCastellsague, Xavieren
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorMerletti, Francoen
dc.contributor.authorRichiardi, Lorenzoen
dc.contributor.authorKjaerheim, Kristinaen
dc.contributor.authorSlamova, Alenaen
dc.contributor.authorSchejbalova, Miriamen
dc.contributor.authorCanova, Cristinaen
dc.contributor.authorSimonato, Lorenzoen
dc.contributor.authorTalamini, Renatoen
dc.contributor.authorBarzan, Luigien
dc.contributor.authorConway, David Ien
dc.contributor.authorMcKinney, Patricia Aen
dc.contributor.authorZnaor, Arianaen
dc.contributor.authorLowry, Raymond Jen
dc.contributor.authorThomson, Peteren
dc.contributor.authorHealy, Claire Men
dc.contributor.authorMcCartan, Bernard Een
dc.contributor.authorMarron, Manuelaen
dc.contributor.authorHashibe, Miaen
dc.contributor.authorBrennan, Paulen
dc.date.accessioned2011-03-11T12:44:01Z-
dc.date.available2011-03-11T12:44:01Z-
dc.date.issued2010-12-
dc.identifier.citationThe aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. 2010, 21 (12):2213-21 Cancer Causes Controlen
dc.identifier.issn1573-7225-
dc.identifier.pmid20835759-
dc.identifier.doi10.1007/s10552-010-9641-3-
dc.identifier.urihttp://hdl.handle.net/10147/124253-
dc.description.abstractThe incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption.-
dc.description.abstractTo determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years.-
dc.description.abstractA case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched.-
dc.description.abstractThere were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk.-
dc.description.abstractRisk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike.-
dc.language.isoenen
dc.titleThe aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study.en
dc.typeArticleen
dc.contributor.departmentSchool of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. Tatiana.Macfarlane@abdn.ac.uk.en
dc.identifier.journalCancer causes & control : CCCen
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.