Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

Hdl Handle:
http://hdl.handle.net/10147/124115
Title:
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
Affiliation:
Department of Genetics, University of North Carolina, Chapel Hill, NC 27710, USA.
Citation:
Genome-wide meta-analyses identify multiple loci associated with smoking behavior. 2010, 42 (5):441-7 Nat. Genet.
Journal:
Nature genetics
Issue Date:
May-2010
URI:
http://hdl.handle.net/10147/124115
DOI:
10.1038/ng.571
PubMed ID:
20418890
Abstract:
Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.03, standard error (s.e.) = 0.053, P = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], beta = 0.367, s.e. = 0.059, P = 5.7 x 10(-10); and rs1028936[A], beta = 0.446, s.e. = 0.074, P = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], beta = 0.333, s.e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.
Item Type:
Article
Language:
en
MeSH:
Age Factors; Alleles; Chromosome Mapping; Female; Genome; Genome-Wide Association Study; Genotype; Humans; Male; Molecular Epidemiology; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Smoking
ISSN:
1546-1718

Full metadata record

DC FieldValue Language
dc.date.accessioned2011-03-10T13:31:47Z-
dc.date.available2011-03-10T13:31:47Z-
dc.date.issued2010-05-
dc.identifier.citationGenome-wide meta-analyses identify multiple loci associated with smoking behavior. 2010, 42 (5):441-7 Nat. Genet.en
dc.identifier.issn1546-1718-
dc.identifier.pmid20418890-
dc.identifier.doi10.1038/ng.571-
dc.identifier.urihttp://hdl.handle.net/10147/124115-
dc.description.abstractConsistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.03, standard error (s.e.) = 0.053, P = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], beta = 0.367, s.e. = 0.059, P = 5.7 x 10(-10); and rs1028936[A], beta = 0.446, s.e. = 0.074, P = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], beta = 0.333, s.e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.-
dc.language.isoenen
dc.subject.meshAge Factors-
dc.subject.meshAlleles-
dc.subject.meshChromosome Mapping-
dc.subject.meshFemale-
dc.subject.meshGenome-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMolecular Epidemiology-
dc.subject.meshOdds Ratio-
dc.subject.meshPhenotype-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshReceptors, Nicotinic-
dc.subject.meshSmoking-
dc.titleGenome-wide meta-analyses identify multiple loci associated with smoking behavior.en
dc.typeArticleen
dc.contributor.departmentDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27710, USA.en
dc.identifier.journalNature geneticsen
dc.description.provinceLeinster-

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