Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.

Hdl Handle:
http://hdl.handle.net/10147/124014
Title:
Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.
Authors:
Lagiou, Pagona; Georgila, Christina; Minaki, Ploumitsa; Ahrens, Wolfgang; Pohlabeln, Hermann; Benhamou, Simone; Bouchardy, Christine; Slamova, Alena; Schejbalova, Miriam; Merletti, Franco; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsague, Xavier; Macfarlane, Tatiana V; Macfarlane, Gary J; Talamini, Renato; Barzan, Luigi; Canova, Cristina; Simonato, Lorenzo; Lowry, Ray; Conway, David I; McKinney, Patricia A; Znaor, Ariana; McCartan, Bernard E; Healy, Claire; Nelis, Mari; Metspalu, Andres; Marron, Manuela; Hashibe, Mia; Brennan, Paul J
Affiliation:
Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece.
Citation:
Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection. 2009, 18 (1):76-84 Eur. J. Cancer Prev.
Journal:
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10147/124014
DOI:
10.1097/CEJ.0b013e32830c8dca
PubMed ID:
18830131
Abstract:
Cancers of the upper aerodigestive tract (UADT) include those of the oral cavity, pharynx (other than nasopharynx), larynx, and esophagus. Tobacco smoking and consumption of alcoholic beverages are established causes of UADT cancers, whereas reduced intake of vegetables and fruits are likely causes. The role of genetic predisposition and possible interactions of genetic with exogenous factors, however, have not been adequately studied. Moreover, the role of pattern of smoking and drinking, as well as the exact nature of the implicated dietary variables, has not been clarified. To address these issues, the International Agency for Research on Cancer initiated in 2002 the alcohol-related cancers and genetic susceptibility (ARCAGE) in Europe project, with the participation of 15 centers in 11 European countries. Information and biological data from a total of 2304 cases and 2227 controls have been collected and will be used in a series of analyses. A total of 166 single nucleotide polymorphisms of 76 genes are being studied for genetic associations with UADT cancers. We report here the methodology of the ARCAGE project, main demographic and lifestyle characteristics of the cases and controls, as well as the distribution of cases by histology and subsite. About 80% of cases were males and fewer than 20% of all cases occurred before the age of 50 years. Overall, the most common subsite was larynx, followed by oral cavity, oropharynx, esophagus and hypopharynx. Close to 90% of UADT cancers were squamous cell carcinomas. A clear preponderance of smokers and alcohol drinkers among UADT cases compared with controls was observed.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Case-Control Studies; Data Collection; Europe; Female; Genetic Predisposition to Disease; Head and Neck Neoplasms; Humans; Life Style; Male; Middle Aged
ISSN:
1473-5709

Full metadata record

DC FieldValue Language
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorGeorgila, Christinaen
dc.contributor.authorMinaki, Ploumitsaen
dc.contributor.authorAhrens, Wolfgangen
dc.contributor.authorPohlabeln, Hermannen
dc.contributor.authorBenhamou, Simoneen
dc.contributor.authorBouchardy, Christineen
dc.contributor.authorSlamova, Alenaen
dc.contributor.authorSchejbalova, Miriamen
dc.contributor.authorMerletti, Francoen
dc.contributor.authorRichiardi, Lorenzoen
dc.contributor.authorKjaerheim, Kristinaen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorCastellsague, Xavieren
dc.contributor.authorMacfarlane, Tatiana Ven
dc.contributor.authorMacfarlane, Gary Jen
dc.contributor.authorTalamini, Renatoen
dc.contributor.authorBarzan, Luigien
dc.contributor.authorCanova, Cristinaen
dc.contributor.authorSimonato, Lorenzoen
dc.contributor.authorLowry, Rayen
dc.contributor.authorConway, David Ien
dc.contributor.authorMcKinney, Patricia Aen
dc.contributor.authorZnaor, Arianaen
dc.contributor.authorMcCartan, Bernard Een
dc.contributor.authorHealy, Claireen
dc.contributor.authorNelis, Marien
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorMarron, Manuelaen
dc.contributor.authorHashibe, Miaen
dc.contributor.authorBrennan, Paul Jen
dc.date.accessioned2011-03-09T11:55:16Z-
dc.date.available2011-03-09T11:55:16Z-
dc.date.issued2009-02-
dc.identifier.citationAlcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection. 2009, 18 (1):76-84 Eur. J. Cancer Prev.en
dc.identifier.issn1473-5709-
dc.identifier.pmid18830131-
dc.identifier.doi10.1097/CEJ.0b013e32830c8dca-
dc.identifier.urihttp://hdl.handle.net/10147/124014-
dc.description.abstractCancers of the upper aerodigestive tract (UADT) include those of the oral cavity, pharynx (other than nasopharynx), larynx, and esophagus. Tobacco smoking and consumption of alcoholic beverages are established causes of UADT cancers, whereas reduced intake of vegetables and fruits are likely causes. The role of genetic predisposition and possible interactions of genetic with exogenous factors, however, have not been adequately studied. Moreover, the role of pattern of smoking and drinking, as well as the exact nature of the implicated dietary variables, has not been clarified. To address these issues, the International Agency for Research on Cancer initiated in 2002 the alcohol-related cancers and genetic susceptibility (ARCAGE) in Europe project, with the participation of 15 centers in 11 European countries. Information and biological data from a total of 2304 cases and 2227 controls have been collected and will be used in a series of analyses. A total of 166 single nucleotide polymorphisms of 76 genes are being studied for genetic associations with UADT cancers. We report here the methodology of the ARCAGE project, main demographic and lifestyle characteristics of the cases and controls, as well as the distribution of cases by histology and subsite. About 80% of cases were males and fewer than 20% of all cases occurred before the age of 50 years. Overall, the most common subsite was larynx, followed by oral cavity, oropharynx, esophagus and hypopharynx. Close to 90% of UADT cancers were squamous cell carcinomas. A clear preponderance of smokers and alcohol drinkers among UADT cases compared with controls was observed.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlcohol Drinking-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCase-Control Studies-
dc.subject.meshData Collection-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshLife Style-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.titleAlcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.en
dc.typeArticleen
dc.contributor.departmentDepartment of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece.en
dc.identifier.journalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)en
dc.description.provinceLeinster-

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