Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial.

Hdl Handle:
http://hdl.handle.net/10147/121246
Title:
Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial.
Authors:
Kirwan, Patrick; Jackson, Andrew L; Asaolu, Samuel O; Molloy, Sile F; Abiona, Titilayo C; Bruce, Marian C; Ranford-Cartwright, Lisa; O' Neill, Sandra M; Holland, Celia V
Affiliation:
Department of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland. kirwanpa@tcd.ie
Citation:
Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. 2010, 10:277 BMC Infect. Dis.
Journal:
BMC infectious diseases
Issue Date:
2010
URI:
http://hdl.handle.net/10147/121246
DOI:
10.1186/1471-2334-10-277
PubMed ID:
20858280
Abstract:
Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children.; A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.; 320 Children (out of 1228, 26.1%) complied with all the follow-up assessments. Plasmodium prevalence and mean Plasmodium parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having Plasmodium infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean Plasmodium density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in Plasmodium density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.; Repeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of Plasmodium infection in preschool children which coincided with a reduction in both the prevalence and intensity of A. lumbricoides infections.; Current controlled trials ISRCTN44215995.
Item Type:
Article
Language:
en
MeSH:
Albendazole; Animals; Anthelmintics; Ascariasis; Ascaris lumbricoides; Child, Preschool; Double-Blind Method; Female; Humans; Infant; Malaria; Male; Placebos; Treatment Outcome
ISSN:
1471-2334

Full metadata record

DC FieldValue Language
dc.contributor.authorKirwan, Patricken
dc.contributor.authorJackson, Andrew Len
dc.contributor.authorAsaolu, Samuel Oen
dc.contributor.authorMolloy, Sile Fen
dc.contributor.authorAbiona, Titilayo Cen
dc.contributor.authorBruce, Marian Cen
dc.contributor.authorRanford-Cartwright, Lisaen
dc.contributor.authorO' Neill, Sandra Men
dc.contributor.authorHolland, Celia Ven
dc.date.accessioned2011-02-04T11:06:53Z-
dc.date.available2011-02-04T11:06:53Z-
dc.date.issued2010-
dc.identifier.citationImpact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. 2010, 10:277 BMC Infect. Dis.en
dc.identifier.issn1471-2334-
dc.identifier.pmid20858280-
dc.identifier.doi10.1186/1471-2334-10-277-
dc.identifier.urihttp://hdl.handle.net/10147/121246-
dc.description.abstractHelminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children.-
dc.description.abstractA double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.-
dc.description.abstract320 Children (out of 1228, 26.1%) complied with all the follow-up assessments. Plasmodium prevalence and mean Plasmodium parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having Plasmodium infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean Plasmodium density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in Plasmodium density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.-
dc.description.abstractRepeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of Plasmodium infection in preschool children which coincided with a reduction in both the prevalence and intensity of A. lumbricoides infections.-
dc.description.abstractCurrent controlled trials ISRCTN44215995.-
dc.language.isoenen
dc.subject.meshAlbendazole-
dc.subject.meshAnimals-
dc.subject.meshAnthelmintics-
dc.subject.meshAscariasis-
dc.subject.meshAscaris lumbricoides-
dc.subject.meshChild, Preschool-
dc.subject.meshDouble-Blind Method-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMalaria-
dc.subject.meshMale-
dc.subject.meshPlacebos-
dc.subject.meshTreatment Outcome-
dc.titleImpact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial.en
dc.typeArticleen
dc.contributor.departmentDepartment of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland. kirwanpa@tcd.ieen
dc.identifier.journalBMC infectious diseasesen

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