Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes.

Hdl Handle:
http://hdl.handle.net/10147/107994
Title:
Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes.
Authors:
Tamagno, Gianluca; Celik, Yahya; Simó, Rafael; Dihné, Marcel; Kimura, Kazumi; Gelosa, Giorgio; Lee, Byung I; Hommet, Caroline; Murialdo, Giovanni
Affiliation:
Department of Endocrinology and Diabetes Mellitus, St Vincent's University Hospital, University College Dublin, Dublin, Ireland. gianluca.tamagno@ucd.ie
Citation:
Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes. 2010, 10:27 BMC Neurol
Journal:
BMC neurology
Issue Date:
2010
URI:
http://hdl.handle.net/10147/107994
DOI:
10.1186/1471-2377-10-27
PubMed ID:
20426819
Abstract:
BACKGROUND: The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported. METHODS: We have recorded and analyzed the clinical, biological, radiological, and electrophysiological findings and the data on the therapeutic management of all GD patients with EAATD reported so far as well as the clinical outcomes in those followed-up in the long term. RESULTS: Twelve of the fourteen patients with EAATD and GD were women. The majority of GD patients with EAATD presented with mild hyperthyroidism at EAATD onset or shortly before it. Active anti-thyroid autoimmunity was detected in all cases. Most of the patients dramatically responded to corticosteroids. The long term clinical outcome was benign but EAATD can relapse, especially at the time of corticosteroid dose tapering or withdrawal. GD and HT patients with EAATD present with a similar clinical, biological, radiological, and electrophysiological picture and require an unaffected EAATD management. CONCLUSIONS: GD and HT equally represent the possible background condition for the development of EAATD, which should be considered in the differential diagnosis of all patients with encephalopathy of unknown origin and an autoimmune thyroid disease, regardless of the nature of the underlying autoimmune thyroid disease.
Language:
en
MeSH:
Adolescent; Adrenal Cortex Hormones; Adult; Aged; Autoantibodies; Child; Electroencephalography; Encephalitis; Female; Follow-Up Studies; Graves Disease; Humans; Male; Middle Aged; Thyroiditis, Autoimmune; Treatment Outcome; Young Adult
ISSN:
1471-2377

Full metadata record

DC FieldValue Language
dc.contributor.authorTamagno, Gianlucaen
dc.contributor.authorCelik, Yahyaen
dc.contributor.authorSimó, Rafaelen
dc.contributor.authorDihné, Marcelen
dc.contributor.authorKimura, Kazumien
dc.contributor.authorGelosa, Giorgioen
dc.contributor.authorLee, Byung Ien
dc.contributor.authorHommet, Carolineen
dc.contributor.authorMurialdo, Giovannien
dc.date.accessioned2010-07-21T08:06:57Z-
dc.date.available2010-07-21T08:06:57Z-
dc.date.issued2010-
dc.identifier.citationEncephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes. 2010, 10:27 BMC Neurolen
dc.identifier.issn1471-2377-
dc.identifier.pmid20426819-
dc.identifier.doi10.1186/1471-2377-10-27-
dc.identifier.urihttp://hdl.handle.net/10147/107994-
dc.description.abstractBACKGROUND: The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported. METHODS: We have recorded and analyzed the clinical, biological, radiological, and electrophysiological findings and the data on the therapeutic management of all GD patients with EAATD reported so far as well as the clinical outcomes in those followed-up in the long term. RESULTS: Twelve of the fourteen patients with EAATD and GD were women. The majority of GD patients with EAATD presented with mild hyperthyroidism at EAATD onset or shortly before it. Active anti-thyroid autoimmunity was detected in all cases. Most of the patients dramatically responded to corticosteroids. The long term clinical outcome was benign but EAATD can relapse, especially at the time of corticosteroid dose tapering or withdrawal. GD and HT patients with EAATD present with a similar clinical, biological, radiological, and electrophysiological picture and require an unaffected EAATD management. CONCLUSIONS: GD and HT equally represent the possible background condition for the development of EAATD, which should be considered in the differential diagnosis of all patients with encephalopathy of unknown origin and an autoimmune thyroid disease, regardless of the nature of the underlying autoimmune thyroid disease.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdrenal Cortex Hormones-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAutoantibodies-
dc.subject.meshChild-
dc.subject.meshElectroencephalography-
dc.subject.meshEncephalitis-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGraves Disease-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshThyroiditis, Autoimmune-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.titleEncephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes.en
dc.contributor.departmentDepartment of Endocrinology and Diabetes Mellitus, St Vincent's University Hospital, University College Dublin, Dublin, Ireland. gianluca.tamagno@ucd.ieen
dc.identifier.journalBMC neurologyen

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