Delayed cystic fibrosis presentation in children in the absence of newborn screening.

Hdl Handle:
http://hdl.handle.net/10147/107595
Title:
Delayed cystic fibrosis presentation in children in the absence of newborn screening.
Authors:
Jackson, A; Foley, L; Daly, L; Fitzpatrick, P; Harrington, M; Zhou, S; Kelleher, C
Affiliation:
UCD School of Public Health, Physiotherapy and Population Science, Woodview Hse, UCD, Belfield, Dublin 4. abaigeal.jackson@ucd.ie
Citation:
Delayed cystic fibrosis presentation in children in the absence of newborn screening. 2010, 103 (4):113-6 Ir Med J
Journal:
Irish medical journal
Issue Date:
Apr-2010
URI:
http://hdl.handle.net/10147/107595
PubMed ID:
20486315
Abstract:
Newborn cystic fibrosis (CF) screening facilitates early diagnosis and nutritional intervention, which prevents malnourishment and improves growth in childhood. To provide baseline information on the natural history of CF in the Republic of Ireland, where newborn screening has not yet been introduced and CF incidence is high (1:1353 live births), we examined the effect of presentation mode, symptom type and gender on age at diagnosis. Median age at diagnosis was calculated by gender and for presentation mode/symptom type for 601 CF registry children diagnosed 1986-2007. Modes of presentation were each significantly associated with delayed presentation. An adjusted odds ratio of 4.5 (95% CI: 1.8, 11.1) was determined for presentation with family history, 43.1 for gastrointestinal symptoms presentation (95% CI: 18.3, 101.4), 96.9 for both respiratory and gastrointestinal symptoms (95% CI: 38.6, 243,4), and 115.4 for respiratory symptoms (95% CI: 45.2, 294.7). Children with respiratory symptoms had the greatest likelihood of delayed diagnosis (median age: 20.4 months), followed by those with respiratory and gastrointestinal symptoms (9.2 months). Gender was not significantly associated with a delayed presentation when presentation mode was taken into account.
Language:
en
MeSH:
Adolescent; Adult; Cystic Fibrosis; Female; Humans; Infant, Newborn; Logistic Models; Male; Middle Aged; Neonatal Screening; Odds Ratio; Time Factors; Young Adult
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorJackson, Aen
dc.contributor.authorFoley, Len
dc.contributor.authorDaly, Len
dc.contributor.authorFitzpatrick, Pen
dc.contributor.authorHarrington, Men
dc.contributor.authorZhou, Sen
dc.contributor.authorKelleher, Cen
dc.date.accessioned2010-07-14T08:18:43Z-
dc.date.available2010-07-14T08:18:43Z-
dc.date.issued2010-04-
dc.identifier.citationDelayed cystic fibrosis presentation in children in the absence of newborn screening. 2010, 103 (4):113-6 Ir Med Jen
dc.identifier.issn0332-3102-
dc.identifier.pmid20486315-
dc.identifier.urihttp://hdl.handle.net/10147/107595-
dc.description.abstractNewborn cystic fibrosis (CF) screening facilitates early diagnosis and nutritional intervention, which prevents malnourishment and improves growth in childhood. To provide baseline information on the natural history of CF in the Republic of Ireland, where newborn screening has not yet been introduced and CF incidence is high (1:1353 live births), we examined the effect of presentation mode, symptom type and gender on age at diagnosis. Median age at diagnosis was calculated by gender and for presentation mode/symptom type for 601 CF registry children diagnosed 1986-2007. Modes of presentation were each significantly associated with delayed presentation. An adjusted odds ratio of 4.5 (95% CI: 1.8, 11.1) was determined for presentation with family history, 43.1 for gastrointestinal symptoms presentation (95% CI: 18.3, 101.4), 96.9 for both respiratory and gastrointestinal symptoms (95% CI: 38.6, 243,4), and 115.4 for respiratory symptoms (95% CI: 45.2, 294.7). Children with respiratory symptoms had the greatest likelihood of delayed diagnosis (median age: 20.4 months), followed by those with respiratory and gastrointestinal symptoms (9.2 months). Gender was not significantly associated with a delayed presentation when presentation mode was taken into account.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshCystic Fibrosis-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeonatal Screening-
dc.subject.meshOdds Ratio-
dc.subject.meshTime Factors-
dc.subject.meshYoung Adult-
dc.titleDelayed cystic fibrosis presentation in children in the absence of newborn screening.en
dc.contributor.departmentUCD School of Public Health, Physiotherapy and Population Science, Woodview Hse, UCD, Belfield, Dublin 4. abaigeal.jackson@ucd.ieen
dc.identifier.journalIrish medical journalen

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