http://hdl.handle.net/10147/220777 Fri, 24 May 2013 00:35:47 GMT 2013-05-24T00:35:47Z http://hdl.handle.net/10147/240214 Title: Patient knowledge of risk factors 18 months after a nurse-led vascular intervention Authors: Tone, J M; Gallagher, P; Agha, A; Thompson, C J Abstract: Background and aims: Eighteen months after the completion of a vascular risk intervention study, the authors aimed to ascertain whether participants who attended the intensive, nurse-led group had better retention of knowledge of diabetes and heart disease compared with those who had undergone standard diabetes care. Method: A knowledge-based questionnaire was sent to participants who completed the vascular risk intervention study, 94 from the intensive, nurse-led group and 94 from the standard care group. Results: A response rate of 75% was achieved. Although more participants in the intensive group achieved recommended vascular risk targets, there was no increase in retained knowledge of vascular risks. A high proportion of the total cohort could not quantify targets for blood pressure (67.2%), cholesterol (65.1%) or HbA1c (68.1%). Conclusion: In this cohort of people with type 2 diabetes, knowledge retention regarding treatment targets was poor. Education programmes should stress awareness of vascular risk factors and diabetes. Sat, 01 Jan 2011 00:00:00 GMT http://hdl.handle.net/10147/240214 2011-01-01T00:00:00Z http://hdl.handle.net/10147/240195 Title: Paediatric craniopharyngiomas: A comparison of open transcranial surgery V's minimally invasive surgery-reflecting a change in treatment paradigm Authors: Sweeney, K; Crimmins, D; Caird, J; Sattar, T; Allcutt, D Sat, 01 Oct 2011 00:00:00 GMT http://hdl.handle.net/10147/240195 2011-10-01T00:00:00Z http://hdl.handle.net/10147/220783 Title: Dyslipidaemia--hepatic and intestinal cross-talk. Authors: Tomkin, Gerald H Abstract: Cholesterol metabolism is tightly regulated with the majority of de novo cholesterol synthesis occurring in the liver and intestine. 3 Hydroxy-3-methylglutaryl coenzyme A reductase, a major enzyme involved in cholesterol synthesis, is raised in both liver and intestine in diabetic animals. Niemann PickC1-like1 protein regulates cholesterol absorption in the intestine and facilitates cholesterol transport through the liver. There is evidence to suggest that the effect of inhibition of Niemann PickC1-like1 lowers cholesterol through its effect not only in the intestine but also in the liver. ATP binding cassette proteins G5/G8 regulate cholesterol re-excretion in the intestine and in the liver, cholesterol excretion into the bile. Diabetes is associated with reduced ATP binding cassette protein G5/G8 expression in both the liver and intestine in animal models. Microsomal triglyceride transfer protein is central to the formation of the chylomicron in the intestine and VLDL in the liver. Microsomal triglyceride transfer protein mRNA is increased in diabetes in both the intestine and liver. Cross-talk between the intestine and liver is poorly documented in humans due to the difficulty in obtaining liver biopsies but animal studies are fairly consistent in showing relationships that explain in part mechanisms involved in cholesterol homeostasis. Tue, 01 Jun 2010 00:00:00 GMT http://hdl.handle.net/10147/220783 2010-06-01T00:00:00Z http://hdl.handle.net/10147/220743 Title: Desmoplastic malignant melanoma presenting as large lung mass. Authors: Al-Alao, Bassel Suffian; Shuhaibar, Maher Nicolas Abstract: We describe a case of successful minimally invasive thoracoscopic surgical resection of metastatic desmoplastic malignant melanoma replacing the entire right lower lobe of the lung, presenting 4 years after the initial complete resection of the primary scalp lesion. An 89-year-old man presented with a 6-month history of right-sided chest pain. A computed tomographic scan showed a large paravertebral mass with possibility of chest wall invasion. Core biopsy initially raised the suspicion of a schwannoma. We also discussed the atypical delayed presentation and misleading radiologic and histologic findings. Sun, 01 Aug 2010 00:00:00 GMT http://hdl.handle.net/10147/220743 2010-08-01T00:00:00Z