http://hdl.handle.net/10147/128169 Tue, 21 May 2013 06:10:23 GMT 2013-05-21T06:10:23Z http://www.lenus.ie:80/hse/retrieve/281580/stjames.gif http://hdl.handle.net/10147/128169 http://hdl.handle.net/10147/290702 Title: Factors involved in unplanned admissions from general surgical day-care in a modern protected facility Authors: Awan, FN; Zulkifli, MS; Mc Cormack, O; Manzoor, T; Ravi, N; Mehigan, B; Reynolds, JV Wed, 01 May 2013 00:00:00 GMT http://hdl.handle.net/10147/290702 2013-05-01T00:00:00Z http://hdl.handle.net/10147/290724 Title: Incidental detection of colorectal malignancies using FDG PET-CT Authors: Fleming, M; Knox, M; Kennedy, MJ; Johnston, C Wed, 01 May 2013 00:00:00 GMT http://hdl.handle.net/10147/290724 2013-05-01T00:00:00Z http://hdl.handle.net/10147/285032 Title: Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. Authors: Cheallaigh, Clíona Ní; Fitzgerald, Ian; Grace, Jacinta; Singh, Gurmit Jagjit; El-Eraki, Nahla; Gibbons, Noel; Keane, Joseph; Rogers, Thomas R; Clarke, Susan; Bergin, Colm Abstract: Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting. Tue, 01 Jan 2013 00:00:00 GMT http://hdl.handle.net/10147/285032 2013-01-01T00:00:00Z http://hdl.handle.net/10147/281373 Title: Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance. Authors: Finucane, Orla M; Reynolds, Clare M; McGillicuddy, Fiona C; Roche, Helen M Abstract: High-fat diet (HFD)-induced obesity has emerged as a state of chronic low-grade inflammation characterised by a progressive infiltration of immune cells, particularly macrophages, into obese adipose tissue. Adipose tissue macrophages (ATM) present immense plasticity. In early obesity, M2 anti-inflammatory macrophages acquire an M1 pro-inflammatory phenotype. Pro-inflammatory cytokines including TNF-α, IL-6 and IL-1β produced by M1 ATM exacerbate local inflammation promoting insulin resistance (IR), which consequently, can lead to type-2 diabetes mellitus (T2DM). However, the triggers responsible for ATM recruitment and activation are not fully understood. Adipose tissue-derived chemokines are significant players in driving ATM recruitment during obesity. Macrophage migration inhibitory factor (MIF), a chemokine-like inflammatory regulator, is enhanced during obesity and is directly associated with the degree of peripheral IR. This review focuses on the functional role of macrophages in obesity-induced IR and highlights the importance of the unique inflammatory cytokine MIF in propagating obesity-induced inflammation and IR. Given MIF chemotactic properties, MIF may be a primary candidate promoting ATM recruitment during obesity. Manipulating MIF inflammatory activities in obesity, using pharmacological agents or functional foods, may be therapeutically beneficial for the treatment and prevention of obesity-related metabolic diseases. Thu, 01 Nov 2012 00:00:00 GMT http://hdl.handle.net/10147/281373 2012-11-01T00:00:00Z