http://hdl.handle.net/10147/128165 Mon, 20 May 2013 01:59:06 GMT 2013-05-20T01:59:06Z http://www.lenus.ie:80/hse/retrieve/430712/Holles.jpg http://hdl.handle.net/10147/128165 http://hdl.handle.net/10147/292266 Title: Isolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy. Authors: Barrett, Michael Joseph; Donoghue, Veronica; Mooney, Eoghan E; Slevin, Marie; Persaud, Thara; Twomey, Eilish; Ryan, Stephanie; Laffan, Eoghan; Twomey, Anne Abstract: We discuss possible aetiological factors, MRI evolution of injury and neuro-developmental outcomes of neonatal encephalopathy (NE). Thirty-six consecutive infants diagnosed with NE were included. In this cohort, four infants (11%) were identified with injury predominantly in the deep white matter on MRI who were significantly of younger gestation, lower birthweight with higher Apgars at one and five minutes compared to controls. Placental high grade villitis of unknown aetiology (VUA) was identified in all four of these infants. Our hypothesis states VUA may induce white matter injury by causing a local inflammatory response and/or oxidative stress during the perinatal period. We underline the importance of continued close and systematic evaluation of all cases of NE, including examination of the placenta, in order to come to a better understanding of the clinical presentation, the patterns of brain injury and the underlying pathophysiological processes. Fri, 01 Mar 2013 00:00:00 GMT http://hdl.handle.net/10147/292266 2013-03-01T00:00:00Z http://hdl.handle.net/10147/292265 Title: Maternal nutrition among women from Sub-Saharan Africa, with a focus on Nigeria, and potential implications for pregnancy outcomes among immigrant populations in developed countries. Authors: Lindsay, K L; Gibney, E R; McAuliffe, F M Abstract: Pregnant women in countries of Sub-Saharan Africa (SSA) are at risk of poor nutritional status and adverse outcomes as a result of poverty, food insecurity, sub-optimal healthcare facilities, frequent infections and frequent pregnancies. Studies from Nigeria, for example, have revealed a high prevalence of both under- and over-nutrition, as well as nutrient deficiencies, including iron, folate, vitamin D and vitamin A. Subsequently, obstetric complications, including hypertension, anaemia, neural tube defects, night-blindness, low birth weight and maternal and perinatal mortality, are common. Migration patterns from SSA to the Western world are on the rise in recent years, with Nigerians now representing the most prevalent immigrant African population in many developed countries. However, the effect of immigration, if any, on the nutritional status and pregnancy outcomes of these women in their host countries has not yet been studied. Consequently, it is unknown to what extent the nutritional deficiencies and pregnancy complications occurring in Nigeria, and other countries of SSA, present in these women post-emigration. This may result in missed opportunities for appropriate antenatal care of a potential high-risk group in pregnancy. The present review discusses the literature regarding nutrition in pregnancy among SSA women, using Nigeria as an example, the common nutrition-related complications that arise and the subsequent obstetric outcomes. The concept of dietary acculturation among immigrant groups is also discussed and deficiencies in the literature regarding studies on the diets of pregnant immigrant women are highlighted. Sat, 01 Dec 2012 00:00:00 GMT http://hdl.handle.net/10147/292265 2012-12-01T00:00:00Z http://hdl.handle.net/10147/281372 Title: Pregnancy in dark winters: implications for fetal bone growth? Authors: Walsh, Jennifer M; Kilbane, Mark; McGowan, Ciara A; McKenna, Malachi J; McAuliffe, Fionnuala M Abstract: To prospectively examine the prevalence of hypovitaminosis D in pregnancy and to correlate maternal and fetal vitamin D to fetal anthropometry. Tue, 01 Jan 2013 00:00:00 GMT http://hdl.handle.net/10147/281372 2013-01-01T00:00:00Z http://hdl.handle.net/10147/273020 Title: Apparent improvement in survival for Carcinoma of the Cervix following the introduction of Chemoradiation a Will Rogers phenomenon Authors: Foley, ME; Ryan, H; Kearney, E; Herlihy, A; Craig, H; Kelehan, P; Mooney, E; Lenehan, P; Flannelly, G Fri, 01 Mar 2013 00:00:00 GMT http://hdl.handle.net/10147/273020 2013-03-01T00:00:00Z