http://hdl.handle.net/10147/124481 Fri, 24 May 2013 08:50:50 GMT 2013-05-24T08:50:50Z http://hdl.handle.net/10147/254902 Title: Psychiatry beyond the current paradigm. Authors: Bracken, Pat; Thomas, Philip; Timimi, Sami; Asen, Eia; Behr, Graham; Beuster, Carl; Bhunnoo, Seth; Browne, Ivor; Chhina, Navjyoat; Double, Duncan; Downer, Simon; Evans, Chris; Fernando, Suman; Garland, Malcolm R; Hopkins, William; Huws, Rhodri; Johnson, Bob; Martindale, Brian; Middleton, Hugh; Moldavsky, Daniel; Moncrieff, Joanna; Mullins, Simon; Nelki, Julia; Pizzo, Matteo; Rodger, James; Smyth, Marcellino; Summerfield, Derek; Wallace, Jeremy; Yeomans, David Abstract: A series of editorials in this Journal have argued that psychiatry is in the midst of a crisis. The various solutions proposed would all involve a strengthening of psychiatry's identity as essentially 'applied neuroscience'. Although not discounting the importance of the brain sciences and psychopharmacology, we argue that psychiatry needs to move beyond the dominance of the current, technological paradigm. This would be more in keeping with the evidence about how positive outcomes are achieved and could also serve to foster more meaningful collaboration with the growing service user movement. Sat, 01 Dec 2012 00:00:00 GMT http://hdl.handle.net/10147/254902 2012-12-01T00:00:00Z http://hdl.handle.net/10147/204629 Title: A novel mutation in the calcium-sensing receptor gene in an Irish pedigree showing familial hypocalciuric hypercalcemia: a case report. Authors: Elamin, Wael F; de Buyl, Olivier Abstract: Familial hypocalciuric hypercalcemia is a rare autosomal dominant disorder characterized by asymptomatic and non-progressive hypercalcemia due to mutations of the calcium-sensing receptor gene. Disorders of calcium metabolism are very common in the elderly, and they can coexist with familial hypocalciuric hypercalcemia in affected families.; We describe an Irish family with hypercalcemia and hypocalciuria. The proband, an 80-year-old Irish woman, presented with hypercalcemia, relative hypocalciuria, and an elevated parathormone level. She also had chronic kidney disease stage 3 and vitamin D deficiency. Two of her sons were also found to be hypercalcemic and hypocalciuric. DNA sequencing identified a novel missense inactivating mutation in the calcium sensing-receptor gene of the proband and her two hypercalcemic sons.; Familial hypocalciuric hypercalcemia due to a novel mutation in the calcium-sensing receptor gene was diagnosed in the proband and her two sons. Disorders of calcium metabolism can be multifarious in the elderly. We suggest that testing first degree relatives for calcium levels and DNA sequencing may have a role in the assessment of elderly patients with parathormone-related hypercalcemia. Fri, 01 Jan 2010 00:00:00 GMT http://hdl.handle.net/10147/204629 2010-01-01T00:00:00Z http://hdl.handle.net/10147/124484 Title: Medicine in old age: a clinical approach Authors: Mulkerrin, EC Prof.; Carey, Brian Dr.; Liston, Richard Dr. Thu, 01 Jan 2009 00:00:00 GMT http://hdl.handle.net/10147/124484 2009-01-01T00:00:00Z