http://hdl.handle.net/10147/122660 Mon, 20 May 2013 01:11:53 GMT 2013-05-20T01:11:53Z http://hdl.handle.net/10147/292283 Title: Comparison of serum Dkk1 (Dickkopf-1) and bone mineral density in patients on bisphosphonate treatment vs no treatment. Authors: Memon, Adeel R; Butler, Joseph S; O'Riordan, Michael V; Guerin, Elizabeth; Dimitrov, Borislav D; Harty, James A Abstract: Complex pathways affect bone metabolism at the cellular level, and a balance between osteoblast and osteoclast activity is critical to bone remodeling. One of the major pathways affecting bone metabolism is Wnt/β-catenin signaling, and its disturbances lead to a wide range of bone abnormalities. An important antagonist of this pathway is Dickkopf-1 (Dkk1). Higher Dkk1 levels have been associated with increased bone loss due to inhibition of Wnt pathway. Currently, bisphosphonates are the most commonly used agents to treat primary osteoporotic patients. This study demonstrates the effect of bisphosphonates on Dkk1 levels and its correlation with bone mineral density (BMD). Eighty patients with low BMD were recruited and divided into 2 groups of 40 each (bisphosphonate treatment group and control group). The mean Dkk1 level in the treatment group was significantly reduced to 2358.18 vs 3749.80 pg/mL in the control group (p<0.001). Pearson correlation coefficient showed negative correlation between Dkk1 and BMD at lumbar spine (r=-0.55) and femoral neck in the control group; however, no such correlation was found in the treatment group (r=-0.05). Hence, bisphosphonate therapy leads to reduction in Dkk1 levels, but it does not correlate with BMD in such patients. Fri, 17 May 2013 00:00:00 GMT http://hdl.handle.net/10147/292283 2013-05-17T00:00:00Z http://hdl.handle.net/10147/290723 Title: The impact of rolling theatre closures on core urology training Authors: Good, DW; Khan, N; Kiely, E; Brady, C Wed, 01 May 2013 00:00:00 GMT http://hdl.handle.net/10147/290723 2013-05-01T00:00:00Z http://hdl.handle.net/10147/290519 Title: Parental patterns of use of over the counter analgesics in children Authors: Garvey, AA; Hawkes, CP; Ryan, CA; Kelly, M Wed, 01 May 2013 00:00:00 GMT http://hdl.handle.net/10147/290519 2013-05-01T00:00:00Z http://hdl.handle.net/10147/288692 Title: A profile of hospital consultants: The health practices of a cohort of medical professionals Authors: O’Cathail, M; O’Callaghan, M Wed, 01 May 2013 00:00:00 GMT http://hdl.handle.net/10147/288692 2013-05-01T00:00:00Z